5 Most Affordable GLP-1 Weight Loss Options in 2025

GLP-1 medications have become a game-changer for weight loss. They work by controlling appetite, slowing digestion, and helping the body manage blood sugar. While their effectiveness is undeniable, cost is often a barrier. In 2025, Zealthy provides multiple options that make GLP-1 medications affordable, accessible, and safe. Through Zealthy, patients can access FDA-approved brand-name drugs as well as compounded versions, all supported with telehealth supervision and coaching.

Here’s a detailed guide to the five most affordable GLP-1 weight-loss medications available through Zealthy and how you can use them to achieve your weight-loss goals safely.

Zepbound (Tirzepatide)

Zepbound is a dual-action GLP-1 and GIP medication, making it one of the most effective weight-loss treatments available today. Clinical studies show patients can lose up to 20–25% of body weight over several months.

Why Zealthy Makes It Affordable:

For insured patients, Zealthy’s team coordinates prior authorization to reduce out-of-pocket costs, sometimes as low as $25/month.
Provides prescription management, coaching, and ongoing medical supervision.
Personalized dose escalation minimizes side effects like nausea, vomiting, and digestive discomfort.

Zepbound through Zealthy is ideal for patients seeking highly effective, insurance-supported weight-loss solutions with professional guidance every step of the way.

Wegovy (Semaglutide)

Wegovy is a high-dose semaglutide medication designed specifically for weight loss. Unlike other GLP-1 drugs initially developed for diabetes, Wegovy has been clinically studied and FDA-approved for obesity management. Zealthy supports Wegovy for patients who have insurance coverage, helping them navigate prior authorization and cost reduction. With successful insurance approval, monthly costs can drop to approximately $25, making it highly affordable.

Patients using Wegovy often experience gradual but consistent weight loss. Zealthy’s program ensures users are not just taking medication but also receiving coaching support, lifestyle guidance, and medical supervision. The combination of drug therapy with behavioral support improves long-term results.

Like all GLP-1s, Wegovy can cause side effects, including mild nausea, constipation, or stomach discomfort. Zealthy’s care team monitors patients closely, adjusting doses and offering guidance to manage side effects. This approach makes Wegovy a safe and reliable option for insured users seeking an affordable path to weight loss.

Zealthy Benefits:

Zealthy assists insured patients with prior authorization and cost reduction, sometimes bringing monthly expenses down to $25.
Patients receive medical supervision, coaching, and lifestyle guidance, ensuring optimal results.
Side effects like nausea, constipation, or mild stomach discomfort are managed with Zealthy’s professional support.

This makes Wegovy an affordable and safe choice for insured users aiming for long-term weight management.

Ozempic (Semaglutide)

Ozempic is another semaglutide-based GLP-1 medication. Originally approved for type 2 diabetes, it is frequently prescribed off-label for weight loss. Zealthy supports Ozempic as a weight-loss option for patients with insurance, guiding them through prior authorization and insurance approvals.

Ozempic provides effective weight loss similar to Wegovy, though its FDA-approved dose is lower for diabetes management. Patients under Zealthy’s program benefit from medical supervision, coaching, and ongoing dose monitoring. This ensures the medication works effectively for weight management while minimizing side effects.

For some patients, Ozempic may be more accessible or better covered by insurance than Wegovy. Zealthy’s insurance team can assess the best option for each individual, making it a practical and affordable solution for weight loss.

Why Use Ozempic via Zealthy:

Provides similar weight-loss benefits under medical supervision.
Zealthy offers coaching, dose monitoring, and telehealth support for consistent, safe results.
Insurance coordination ensures lower out-of-pocket costs for eligible patients.

Ozempic is an excellent option for those seeking a flexible, insurance-supported GLP-1 solution.

Mounjaro (Tirzepatide)

Mounjaro is a tirzepatide medication initially approved for type 2 diabetes but can also be used for weight management under Zealthy’s supervision. It is highly effective, particularly for patients who have struggled with other GLP-1 options. Zealthy helps coordinate insurance coverage for Mounjaro, making it more affordable for patients who qualify.

This medication works similarly to Zepbound by targeting both GLP-1 and GIP receptors, enhancing appetite suppression and metabolic benefits. Users often notice significant weight reduction when combined with lifestyle changes and support from Zealthy’s coaching program.

Side effects of mounjaro such as nausea, vomiting, or digestive issues can occur, particularly during initial dose escalation. Zealthy provides guidance and monitoring to help patients manage these effects. For those whose insurance favors diabetes medications, Mounjaro may be a cost-effective and practical GLP-1 option.

Zealthy Advantages:

Zealthy assists with insurance coverage, making it more affordable for qualifying patients.
Combines medication with coaching and lifestyle support to maximize results.
Side effects during dose escalation are monitored closely to ensure safe and comfortable use.

Mounjaro is suitable for patients who have struggled with other GLP-1 medications and seek powerful weight-loss support.

Compounded Semaglutide and Tirzepatide

For patients without insurance or those seeking lower-cost alternatives, Zealthy offers compounded versions of semaglutide and tirzepatide. These medications contain the same active ingredients as the brand-name versions but are prepared by licensed, sterile compounding pharmacies.

Compounded semaglutide costs as low as $151 per month when purchasing a three-month supply through Zealthy. Compounded tirzepatide is slightly higher, around $216 per month for the same supply. These prices are significantly more affordable than brand-name medications and provide access to the same clinically effective molecules.

Although compounded medications are not FDA-approved in the same way as their branded counterparts, Zealthy ensures all compounding is done safely and under strict standards. Medical supervision, coaching, and dose monitoring remain a part of the program, making these options safe and effective for weight loss.

Compounded GLP-1s are ideal for patients who cannot use insurance, want to save money, or prefer the flexibility of cash-pay options. Zealthy’s program ensures that users still receive comprehensive care and support.

Pricing through Zealthy:

Compounded semaglutide: $151/month (3-month supply)
Compounded tirzepatide: $216/month (3-month supply)

Benefits:

Lower cost without sacrificing efficacy.
Full medical supervision, coaching, and dose monitoring included.
Ideal for cash-pay patients seeking flexibility and affordability.

Choosing the Right GLP-1

Selecting the right GLP-1 option depends on your goals, insurance coverage, and budget. Brand-name medications like Zepbound and Wegovy are typically the most affordable with insurance, thanks to Zealthy’s coordination and prior authorization assistance. Off-label options like Ozempic or Mounjaro may also provide excellent results depending on your insurance plan.

For cash-pay patients or those without insurance, compounded semaglutide and tirzepatide offer the most cost-effective options. These medications provide access to the same active ingredients as the branded drugs, along with the same level of medical oversight.

Side effects, convenience, and long-term commitment should also be considered. GLP-1 therapy works best when paired with lifestyle changes, including healthy diet habits and exercise. Zealthy’s coaching and support program helps patients integrate these changes for long-term success.

Important Considerations

While Zealthy offers affordable and accessible GLP-1 options, it’s important to understand the risks and limitations. Compounded medications are not FDA-approved in the same way as branded drugs, and quality control can vary. Medical supervision is critical to ensure safety and effectiveness.

Side effects like nausea, constipation, and digestive issues are common, particularly during dose escalation. Zealthy’s program provides support for managing these effects. Insurance coverage can vary, and prior authorization is required for brand-name medications. Approval is not guaranteed, so it’s important to explore both insured and cash-pay options.

GLP-1 therapy is not a short-term solution. Sustained results require long-term commitment, including lifestyle changes and medical monitoring. Zealthy ensures patients receive the guidance, coaching, and support needed to achieve lasting weight loss.

Conclusion

In 2025, Zealthy offers some of the most affordable GLP-1 options available, making weight loss achievable for a wide range of patients. Brand-name medications like Zepbound, Wegovy, Ozempic, and Mounjaro provide effective solutions for insured users, while compounded semaglutide and tirzepatide offer cost-effective alternatives for cash-pay patients.

By combining medical supervision, telehealth convenience, and coaching support, Zealthy ensures patients can use GLP-1 medications safely and effectively. Whether using insurance or choosing compounded options, these programs make it possible to achieve meaningful weight-loss results in a sustainable and medically supported way.

If you are considering GLP-1 therapy for weight loss, Zealthy provides accessible, affordable, and effective options to help you reach your health goals in 2025.